Converse Smith-Martin cell cycle kinetics by transformed B lymphocytes

Activation and cell cycle control of murine B lymphocytes.

The cell cycle of activated murine B lymphocytes (B cells) is controlled by the occupancy of surface membrane-bound immunoglobulin (Ig) and by two types of growth factors, called alpha and beta factors. These growth factors are produced in an endocrine fashion by the interaction of helper T lymphocytes (T cells) with antigen-presenting macrophages (A cells). Antigen is taken up, processed and p...

Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus.

Infection of human B cells with Epstein-Barr virus (EBV) results in activation of the cell cycle and cell growth. To interpret the mechanisms by which EBV activates the cell, we have assayed many proteins involved in control of the G0 and G1 phases of the cell cycle and regulation of apoptosis. In EBV infection most of the changes, including the early induction of cyclin D2, are dependent on ex...

Shedding light on cell cycle control by T and B lymphocytes

T lymphocytes are an important element of the adaptive immune response. While normally quiescent, T cells can replicate rapidly to build an army of antigenspecific cells in only a few days following an immune challenge. Many of the cells created are short-lived and die within the first 2 weeks, whereas other cells return to a quiescent long-lived state and serve as memory cells capable of faste...

Epstein-Barr virus transformed B lymphocytes produce interleukin-5.

Interleukin-5 (IL-5) has previously been isolated only as a product of T lymphocytes. We have found that Epstein-Barr virus transformed B lymphocytes produce large amounts of IL-5 activity in culture supernatants, inducing proliferation of murine BCL1 cells, and supporting the selective growth of eosinophil colonies in semi-solid culture. Production of IL-5 messenger RNA by transformed B-cell l...

Cell cycle kinetics in leukemia.